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SEVENTH FRAMEWORK PROGRAMME

Universitätsklinikum Schleswig-Holstein

Universitätsklinikum Schleswig-Holstein
Klinik für Allgemeine Pädiatrie
Arnold-Heller-Strasse 3, Haus 9
24105 Kiel
Germany

Universitätsklinikum Schleswig-Holstein www.uk-sh.de



Project Leader


Prof. Dr. Paul-Martin Holterhus Prof. Dr. Paul-Martin Holterhus
Project Leader WP04 
Phone: 0049-(0)431-597-1626 
Fax: 0049-(0)431-597-1675 
E-Mail to Prof. Dr. Paul-Martin Holterhus Contact  
 

Prof. Dr. Reiner Siebert
Phone: 0049-(0)431-597-1775 
Fax: 0049-(0)431-597-1880 
E-Mail to Prof. Dr. Reiner Siebert Contact  
 

PD Dr. Felix Riepe PD Dr. Felix Riepe
Project Leader WP05 
Phone: +49-(0)431-597-1797  
Fax: +49-(0)431-597-1675  
E-Mail to PD Dr. Felix Riepe Contact  
 



Project Staff


Dr. Ole Ammerpohl
Scientist / DNA-methylation analyses (WP04) 

Dr. Susanne Bens
Clinician / DNA-methylation analyses (WP04) 

Mr. Mahesh Appari
PhD student / DNA-methylation, transcription analysis (WP04) 

Mrs. Kerstin Runde
Technician / sample processing (WP04) 

Dr. Alexandra Kulle
Scientist / LC-MSMS analyses (WP05) 

Mrs. Tanja Stampe
Technician / sample processing (WP05) 

Mrs. Christine Marschke
Technician / sample processing (WP05) 


Institute Presentation


The University Hospital of Schleswig Holstein is a clinic of maximum medical care. Emerged from the joining of the University Hospitals of Lübeck and Kiel, it is one of Europe’s largest hospitals. The campus in Kiel is the largest biomedical University campus in Schleswig-Holstein.

In the Division of Pediatric Endocrinology and Diabetes in Kiel (part of the Department of Pediatrics) more than 3000 cases suffering from Pediatric Endocrine diseases are diagnosed and treated annually. One major focus of our group is the diagnosis, treatment and research on developmental disorders caused by hormonal imbalances including DSD. Therefore, a particular DSD team for inter-disciplinary patient management has been established.

The Department of Human Genetics is working closely together with the Division of Pediatric Endocrinology and Diabetes providing the newest high-tech facilities in genome and epigenome research.

The major contribution of our clinic to the European DSD project will be the determination of the impact of DNA methylation for the development of specific DSD-phenotypes in human. These data will provide valuable novel insights into the regulation of human sex development and individual androgenization. In the future, epigenomic markers of prenatal androgen programming may be of help in clinical studies and individual patient counseling with respect to gender. 

The contribution of our clinic in WP05 will be the analysis of steroid hormones in blood. Sex steroid hormones are of great importance for helping the human body to develop towards a male or female appearance. Patients affected by disorders of sex development (DSD) often suffer from disordered sex steroid production. Work package 05 aims at discovering new causes of DSD and at the same time improving the diagnosis and treatment of patients with known causes of DSD. Our laboratory utilizes liquid chromatography - mass spectrometry as state of the art methodology for the detection of all relevant gonadal and adrenal steroids in blood.


Christian-Albrechts-Universität zu Kiel